Objective: To investigate the correlation between polymorphisms in the FOXP3 locus and the susceptibility of allergic rhinitis.
Methods: Two polymorphisms in FOXP3 locus were genotyped in 193 subjects with allergic rhinitis and 191 healthy controls. The polymorphisms were chosen in terms of the information from Hapmap website as well as Haploview version 4.1 program implemented results. PCR-resequencing methods was performed for genotyping. SPSS program version 13.0 was used for statistical analysis.
Results: Heterozygotes of rs3761547 and rs3761548 appeared significant, while only rs3761548 (P = 0.020, OR = 3.12, 95%CI were 1.21 - 8.04) remained significant following application of the Bonferroni correction for multiple testing. Subgroup analysis for the presence of different allergen allergy also showed significant association for house dust mites (rs3761547, P = 0.013, OR = 2.00).
Conclusion: Heterozygous allele in rs3761548 is associated with allergic rhinitis and rs3761547 is related to house dust mites allergic rhinitis.