Objective: To compare the efficacies of different hydration strategies in protecting the renal function of the arteriosclerosis obliterans (ASO) patients undergoing endovascular treatments.
Methods: 40 patients who underwent endovascular treatments for arteriosclerosis obliterans of lower extremities in the Vascular Surgery Department of PLA Hospital from January 2009 to October 2009 were divided into normal (serum creatinine < or = 110 micromol/L) and abnormal (serum creatine > 110 micromol/L) groups according to their baseline serum concentration of creatinine before treatments. Each group was treated by different hydration strategies 12 h before procedures. Changes of serum creatinine and creatinine clearance were measured 6, 24, 48 h after procedures to evaluate the changes of renal function and the effects of different hydration strategies.
Results: No contrast-induced nephropathy (CIN) was observed among the 40 patients. There are significant differences between normal saline hydration group and control group in the changes of serum creatinine and creatinine clearance 24 h and 48 h after exposure to contrast medium for the normal renal function patients (P < 0.05). For the patients pre-existing renal dysfunction, no significant difference was found between Sodium Bicarbonate + Saline group and Saline group in the changes of Scr and Ccr 6, 24, 48 h after exposure to contrast medium (P > 0.05).
Conclusion: Sodium chloride provides a good efficacy for preventing the adverse effect of contrast medium to the renal function of the ASO patients. For the patients pre-existing renal dysfunction, Combination hydration with sodium bicarbonate is not more effective than normal saline alone in preventing contrast-induced renal dysfunction.