Abstract
The activity of an (8-hydroxymethylen)-trieicosanyl acetate compound obtained from chloroform extracts of Senna villosa (Mill.) H.S. Irwin & Barneby (Leguminosae) against Trypanosoma cruzi was evaluated in vivo. Oral doses of 2.1, 8.4, and 33.6 microg/g were tested for 28 days in BALB/c mice infected with T. cruzi. Reduced parasitemia levels of 70.5%, 73.8%, and 80.9%, respectively, were observed. A significant reduction in amastigote nests was detected in the cardiac tissue of treated animals at doses of 8.4 and 33.6 microg/g. The LD50 of (8-hydroxymethylen)-trieicosanyl acetate was impossible to determine because none of the animals died, even at oral doses of 5000 microg/g; consequently, it was impossible to determine the acute oral toxicity in vivo.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetates / isolation & purification
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Acetates / pharmacology*
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Acetates / toxicity
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Administration, Oral
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Animals
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Chagas Disease / drug therapy*
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Chagas Disease / parasitology
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Dose-Response Relationship, Drug
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Eicosanoids / isolation & purification
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Eicosanoids / pharmacology*
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Eicosanoids / toxicity
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Fabaceae / chemistry
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Heart / parasitology
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Mice
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Mice, Inbred BALB C
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Plant Extracts / pharmacology
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Plant Extracts / toxicity
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Toxicity Tests, Acute
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Trypanocidal Agents / isolation & purification
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Trypanocidal Agents / pharmacology*
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Trypanocidal Agents / toxicity
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Trypanosoma cruzi / drug effects*
Substances
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(8-hydroxymethylen)trieicosanyl acetate
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Acetates
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Eicosanoids
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Plant Extracts
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Trypanocidal Agents