Fibrin glue as a drug delivery system

J Control Release. 2010 Nov 20;148(1):49-55. doi: 10.1016/j.jconrel.2010.06.025. Epub 2010 Jul 15.

Abstract

Fibrin glue has been used surgically for decades for hemostasis as well as a sealant. It has also been researched as both a gel for cell delivery and a vehicle for drug delivery. The drug delivery applications for fibrin glue span tissue engineering to chemotherapy and involve several mechanisms for drug matrix interactions and control of release kinetics. Additionally, drugs or factors can be loaded in the gel via impregnation and tethering to the gel through covalent linkages or affinity-based systems. This review highlights recent research of fibrin glue as a drug delivery vehicle.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Bone Morphogenetic Protein 2 / administration & dosage
  • Drug Delivery Systems*
  • Fibrin Tissue Adhesive / administration & dosage*
  • Genetic Vectors
  • Glial Cell Line-Derived Neurotrophic Factor / administration & dosage
  • Humans
  • Transforming Growth Factor beta1 / administration & dosage
  • Vascular Endothelial Growth Factor A / administration & dosage

Substances

  • BMP2 protein, human
  • Bone Morphogenetic Protein 2
  • Fibrin Tissue Adhesive
  • Glial Cell Line-Derived Neurotrophic Factor
  • Transforming Growth Factor beta1
  • Vascular Endothelial Growth Factor A