Background and objectives: Foetal alloimmune thrombocytopenia (FNAIT) is often treated transplacentally with maternally administered i.v. immunoglobulins, but not all foetuses show a consistent platelet increase during such treatment.
Materials and methods: We retrospectively analysed data from a cohort of ten foetuses with FNAIT treated by direct foetal immunoglobulin infusion. Foetal treatment was begun between 17 and 25 weeks and continued until 36 weeks with weekly cordocenteses and foetal immunoglobulin infusions.
Results: While foetal IgG levels increased steadily during weekly IgG infusions, foetal platelet counts remained unchanged.
Conclusion: Our retrospective study presents a unique analysis of a historical cohort, contributing to the ongoing debate about the treatment of choice for foetal alloimmune thrombocytopenia.
© 2010 The Author(s). Vox Sanguinis © 2010 International Society of Blood Transfusion.