Abstract
Labdadienedial and a series of C15,C16-functionalized derivatives were synthesized from commercial (+)-sclareolide and evaluated for their cytotoxic, antimycotic, and antiviral activities. Their precursors were similarly evaluated.
2010 Elsevier Masson SAS. All rights reserved.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Antifungal Agents / chemical synthesis
-
Antifungal Agents / chemistry
-
Antifungal Agents / pharmacology
-
Antifungal Agents / toxicity
-
Antineoplastic Agents / chemical synthesis
-
Antineoplastic Agents / chemistry
-
Antineoplastic Agents / pharmacology
-
Antineoplastic Agents / toxicity
-
Antiviral Agents / chemical synthesis
-
Antiviral Agents / chemistry
-
Antiviral Agents / pharmacology
-
Antiviral Agents / toxicity
-
Chlorocebus aethiops
-
Diterpenes / chemical synthesis*
-
Diterpenes / chemistry
-
Diterpenes / pharmacology*
-
Diterpenes / toxicity
-
Fungi / drug effects
-
HeLa Cells
-
Herpesvirus 1, Human / drug effects
-
Humans
-
Inhibitory Concentration 50
-
Vero Cells
Substances
-
Antifungal Agents
-
Antineoplastic Agents
-
Antiviral Agents
-
Diterpenes
-
labdadienedial
-
sclareolide