Abstract
The acquisition of β-lactamases, such as class B metallo-β-lactamases, in Pseudomonas aeruginosa is detrimental to antimicrobial therapy in hospitalized patients. In Mexico, metallo-β-lactamase IMP-15 has been found to be encoded on the In95 class 1 integron in a major clone of P. aeruginosa. In this work, we describe the variability of this class 1 integron in an epidemic clone of carbapenem-resistant P. aeruginosa clinical isolates highly related to isolates previously described in Mexico.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology
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Carbapenems / pharmacology
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Electrophoresis, Gel, Pulsed-Field
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Endemic Diseases*
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Genetic Variation*
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Humans
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Imipenem / pharmacology
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Integrons / genetics*
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Mexico / epidemiology
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Microbial Sensitivity Tests
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Molecular Sequence Data
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Pseudomonas Infections / epidemiology*
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Pseudomonas Infections / microbiology
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Pseudomonas aeruginosa / drug effects
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Pseudomonas aeruginosa / enzymology*
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Pseudomonas aeruginosa / genetics
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Pseudomonas aeruginosa / isolation & purification
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Sequence Analysis, DNA
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beta-Lactam Resistance / genetics
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beta-Lactamases / genetics*
Substances
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Anti-Bacterial Agents
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Carbapenems
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Imipenem
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beta-Lactamases
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beta-lactamase IMP-15, Pseudomonas aeruginosa
Associated data
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GENBANK/GQ856538
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GENBANK/GQ856539
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GENBANK/GQ856540
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GENBANK/GQ856541
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GENBANK/GQ856542