Variability of the bla(IMP-15)-containing integrons, highly related to In95, on an endemic clone of Pseudomonas aeruginosa in Mexico

Microb Drug Resist. 2010 Sep;16(3):191-5. doi: 10.1089/mdr.2010.0017.

Abstract

The acquisition of β-lactamases, such as class B metallo-β-lactamases, in Pseudomonas aeruginosa is detrimental to antimicrobial therapy in hospitalized patients. In Mexico, metallo-β-lactamase IMP-15 has been found to be encoded on the In95 class 1 integron in a major clone of P. aeruginosa. In this work, we describe the variability of this class 1 integron in an epidemic clone of carbapenem-resistant P. aeruginosa clinical isolates highly related to isolates previously described in Mexico.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Carbapenems / pharmacology
  • Electrophoresis, Gel, Pulsed-Field
  • Endemic Diseases*
  • Genetic Variation*
  • Humans
  • Imipenem / pharmacology
  • Integrons / genetics*
  • Mexico / epidemiology
  • Microbial Sensitivity Tests
  • Molecular Sequence Data
  • Pseudomonas Infections / epidemiology*
  • Pseudomonas Infections / microbiology
  • Pseudomonas aeruginosa / drug effects
  • Pseudomonas aeruginosa / enzymology*
  • Pseudomonas aeruginosa / genetics
  • Pseudomonas aeruginosa / isolation & purification
  • Sequence Analysis, DNA
  • beta-Lactam Resistance / genetics
  • beta-Lactamases / genetics*

Substances

  • Anti-Bacterial Agents
  • Carbapenems
  • Imipenem
  • beta-Lactamases
  • beta-lactamase IMP-15, Pseudomonas aeruginosa

Associated data

  • GENBANK/GQ856538
  • GENBANK/GQ856539
  • GENBANK/GQ856540
  • GENBANK/GQ856541
  • GENBANK/GQ856542