Abstract
A number of N- and S-substituted uracil and thiouracil glycosides were synthesized by coupling reaction of 5,6-dibenzyle pyrimidine derivatives with the corresponding acetobromosugar. The synthesized compounds were tested for their antiviral activity against hepatitis B virus. Plaque reduction infectivity assay was used to determine virus count reduction as a result of treatment with tested compounds which showed moderate to high antiviral activities.
MeSH terms
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Algorithms
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Antiviral Agents / chemical synthesis*
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Antiviral Agents / chemistry
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Antiviral Agents / pharmacology*
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Drug Design
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Glycosides / chemical synthesis*
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Glycosides / chemistry
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Glycosides / pharmacology*
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Hep G2 Cells
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Hepatitis B / drug therapy
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Hepatitis B / virology
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Hepatitis B virus / drug effects*
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Humans
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Inhibitory Concentration 50
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Microbial Sensitivity Tests
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Molecular Structure
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Structure-Activity Relationship
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Thiouracil / analogs & derivatives*
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Thiouracil / chemical synthesis
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Thiouracil / chemistry
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Thiouracil / pharmacology
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Uracil / analogs & derivatives*
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Viral Plaque Assay
Substances
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Antiviral Agents
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Glycosides
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Uracil
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Thiouracil