A neural-network-based adaptive approach is proposed for the leader-following control of multiagent systems. The neural network is used to approximate the agent's uncertain dynamics, and the approximation error and external disturbances are counteracted by employing the robust signal. When there is no control input constraint, it can be proved that all the following agents can track the leader's time-varying state with the tracking error as small as desired. Compared with the related work in the literature, the uncertainty in the agent's dynamics is taken into account; the leader's state could be time-varying; and the proposed algorithm for each following agent is only dependent on the information of its neighbor agents. Finally, the satisfactory performance of the proposed method is illustrated by simulation examples.