Synthesis and antihepatotoxic activity of 2-(substituted-phenyl)-5-(2,3-dihydro-1,4-benzodioxane-2-yl)-1,3,4-oxadiazole derivatives

J Enzyme Inhib Med Chem. 2011 Apr;26(2):216-21. doi: 10.3109/14756366.2010.489899. Epub 2010 Jul 1.

Abstract

Novel 1,3,4-oxadizole derivatives containing the 1,4-dioxane ring system were synthesised starting from 2,3-dihydro-1,4-benzodioxane-2-carbohydrazide. The synthesised compounds were evaluated for antihepatotoxic activity against CCl₄-induced hepatotoxicity in rats. Some compounds demonstrated a significant antihepatotoxic activity comparable to the standard drug Silymarin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Carbon Tetrachloride / chemistry
  • Carbon Tetrachloride Poisoning
  • Chemical and Drug Induced Liver Injury*
  • Dioxanes / chemical synthesis
  • Dioxanes / chemistry
  • Dioxanes / pharmacology
  • Liver / drug effects*
  • Molecular Structure
  • Oxadiazoles / chemical synthesis*
  • Oxadiazoles / chemistry
  • Oxadiazoles / pharmacology*
  • Rats
  • Silymarin / pharmacology

Substances

  • Dioxanes
  • Oxadiazoles
  • Silymarin
  • Carbon Tetrachloride
  • 1,4-dioxane