Abstract
Novel 1,3,4-oxadizole derivatives containing the 1,4-dioxane ring system were synthesised starting from 2,3-dihydro-1,4-benzodioxane-2-carbohydrazide. The synthesised compounds were evaluated for antihepatotoxic activity against CCl₄-induced hepatotoxicity in rats. Some compounds demonstrated a significant antihepatotoxic activity comparable to the standard drug Silymarin.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Carbon Tetrachloride / chemistry
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Carbon Tetrachloride Poisoning
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Chemical and Drug Induced Liver Injury*
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Dioxanes / chemical synthesis
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Dioxanes / chemistry
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Dioxanes / pharmacology
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Liver / drug effects*
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Molecular Structure
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Oxadiazoles / chemical synthesis*
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Oxadiazoles / chemistry
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Oxadiazoles / pharmacology*
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Rats
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Silymarin / pharmacology
Substances
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Dioxanes
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Oxadiazoles
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Silymarin
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Carbon Tetrachloride
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1,4-dioxane