Fluorocyanation of enamines

J Org Chem. 2010 Aug 6;75(15):5367-70. doi: 10.1021/jo1008993.

Abstract

A method for the fluorocyanation of enamines has been described. The reaction involves fluorination of the electron rich double bond with N-F reagent (Selectfluor or NFSI) accompanied by trapping of beta-fluoroiminium cationic intermediate with cyanide nucleophile.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amines / chemistry*
  • Cyanides / chemistry*
  • Fluorine / chemistry*
  • Magnetic Resonance Spectroscopy

Substances

  • Amines
  • Cyanides
  • Fluorine