Abstract
Scavenger receptor-mediated uptake of acetylated low density lipoprotein-derived cholesterol by peritoneal mouse macrophages resulted in decreased activity of the malonyl-CoA inhibitable carnitine palmitoyltransferase and a decrease in the sensitivity of this enzyme to inhibition by malonyl-CoA.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Animals
-
Biological Transport
-
Carnitine O-Palmitoyltransferase / antagonists & inhibitors
-
Carnitine O-Palmitoyltransferase / metabolism*
-
Cells, Cultured
-
Cholesterol / metabolism*
-
Cholesterol Esters / metabolism
-
Humans
-
Kinetics
-
Lipoproteins, LDL / blood
-
Lipoproteins, LDL / metabolism*
-
Macrophages / enzymology*
-
Male
-
Malonyl Coenzyme A / pharmacology*
-
Mice
Substances
-
Cholesterol Esters
-
Lipoproteins, LDL
-
Malonyl Coenzyme A
-
Cholesterol
-
Carnitine O-Palmitoyltransferase