Effects of cholesterol loading of mouse macrophages on carnitine palmitoyltransferase activity and sensitivity to inhibition by malonyl-CoA

Biochem Biophys Res Commun. 1991 Jun 28;177(3):1121-6. doi: 10.1016/0006-291x(91)90655-q.

Abstract

Scavenger receptor-mediated uptake of acetylated low density lipoprotein-derived cholesterol by peritoneal mouse macrophages resulted in decreased activity of the malonyl-CoA inhibitable carnitine palmitoyltransferase and a decrease in the sensitivity of this enzyme to inhibition by malonyl-CoA.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Biological Transport
  • Carnitine O-Palmitoyltransferase / antagonists & inhibitors
  • Carnitine O-Palmitoyltransferase / metabolism*
  • Cells, Cultured
  • Cholesterol / metabolism*
  • Cholesterol Esters / metabolism
  • Humans
  • Kinetics
  • Lipoproteins, LDL / blood
  • Lipoproteins, LDL / metabolism*
  • Macrophages / enzymology*
  • Male
  • Malonyl Coenzyme A / pharmacology*
  • Mice

Substances

  • Cholesterol Esters
  • Lipoproteins, LDL
  • Malonyl Coenzyme A
  • Cholesterol
  • Carnitine O-Palmitoyltransferase