Abstract
Mass spectrometric studies are now playing a leading role in the elucidation of lipopolysaccharide (LPS) structures through the characterization of antigenic polysaccharides, core oligosaccharides and lipid A components including LPS genetic modifications. The conventional MS and MS/MS analyses together with CID fragmentation provide additional structural information complementary to the previous analytical experiments, and thus contribute to an integrated strategy for the simultaneous characterization and correct sequencing of the carbohydrate moiety.
2010 Wiley Periodicals, Inc.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Aeromonas / chemistry
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Bordetella / chemistry
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Carbohydrate Conformation
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Carbohydrate Sequence
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Chemical Fractionation
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Escherichia coli / chemistry
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Escherichia coli K12 / chemistry
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Klebsiella pneumoniae / chemistry
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Lipid A / chemistry
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Lipopolysaccharides / chemistry*
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Mass Spectrometry*
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Molecular Sequence Data
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Molecular Structure
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Moraxella / chemistry
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Oligosaccharides / chemistry
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Salmonella / chemistry
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Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
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Tandem Mass Spectrometry*
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Vibrio / chemistry
Substances
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Lipid A
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Lipopolysaccharides
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Oligosaccharides