Skin wounds are exposed to a complex series of events that usually culminate in wound healing. This process is well known in relation to histological events, although mechanisms that underlie its regulation remain unclear at a molecular level; not only tissue growth factors but also a number of cytokines are involved. In this paper we report our experience in two cases about the treatment of resistant chronic ulcers of lower limbs using GM-CSF human recombinant: rHuGM-CSF as a topic treatment over 8 weeks. The results consist in a complete healing in one patient and in excellent improvement in the other one. Accordingly, we realized the idea that GM-CSF could be included between compounds able in promoting healing, in relation to direct or indirect effects in relation of its topical GM-CSF use. However, further study will be needed to determine dosage, method of application and type of recombinant material to be used for best results.