Plasmid-mediated resistance to cephalosporins in Salmonella enterica serovar Typhi

Masatomo Morita; Nobuko Takai; Jun Terajima; Haruo Watanabe; Manabu Kurokawa; Hiroko Sagara; Kenji Ohnishi; Hidemasa Izumiya

doi:10.1128/AAC.00225-10

Plasmid-mediated resistance to cephalosporins in Salmonella enterica serovar Typhi

Antimicrob Agents Chemother. 2010 Sep;54(9):3991-2. doi: 10.1128/AAC.00225-10. Epub 2010 Jun 28.

Authors

Masatomo Morita¹, Nobuko Takai, Jun Terajima, Haruo Watanabe, Manabu Kurokawa, Hiroko Sagara, Kenji Ohnishi, Hidemasa Izumiya

Affiliation

¹ Department of Bacteriology I, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, Tokyo, 162-8640, Japan.

Abstract

This study characterized a cephalosporin-resistant Salmonella enterica serovar Typhi isolate. The organism possessed a plasmid encoding the CTX-M-15 extended-spectrum-beta-lactamase. This plasmid is the determinant for the phenotype of cephalosporin resistance and is transferrable among Enterobacteriaceae.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / pharmacology*
Cephalosporins / pharmacology*
Drug Resistance, Bacterial / genetics
Microbial Sensitivity Tests
Plasmids / genetics*
Salmonella typhi
beta-Lactamases / genetics

Substances

Anti-Bacterial Agents
Cephalosporins
beta-lactamase CTX-M-15
beta-Lactamases