A bioactive labdane diterpenoid from Curcuma amada and its semisynthetic analogues as antitubercular agents

Sailendra Singh; Jonnala Kotesh Kumar; Dharmendra Saikia; Karuna Shanker; Jay Prakash Thakur; Arvind Singh Negi; Suchitra Banerjee

doi:10.1016/j.ejmech.2010.06.006

A bioactive labdane diterpenoid from Curcuma amada and its semisynthetic analogues as antitubercular agents

Eur J Med Chem. 2010 Sep;45(9):4379-82. doi: 10.1016/j.ejmech.2010.06.006. Epub 2010 Jun 12.

Authors

Sailendra Singh¹, Jonnala Kotesh Kumar, Dharmendra Saikia, Karuna Shanker, Jay Prakash Thakur, Arvind Singh Negi, Suchitra Banerjee

Affiliation

¹ Plant Tissue Culture Division, Central Institute of Medicinal and Aromatic Plants (CIMAP-CSIR), Kukrail Picnic Spot Road, P.O. CIMAP, Lucknow 226015, India.

PMID: 20584563
DOI: 10.1016/j.ejmech.2010.06.006

Abstract

A labdane diterpene dialdehyde was first time isolated from the chloroform extract of rhizomes of Curcuma amada. This compound exhibited antitubercular activity (MIC=500 microg/mL) against Mycobacterium tuberculosis H(37)Rv strain in BACTEC-460 assay. Two of its semisynthetic analogues also exhibited antitubercular activity at 250-500 microg/mL. It is the first report on isolation and antimycobacterial activity of this dialdehyde from C. amada.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antitubercular Agents / chemical synthesis
Antitubercular Agents / chemistry*
Antitubercular Agents / isolation & purification
Antitubercular Agents / pharmacology*
Chromatography, High Pressure Liquid
Curcuma / chemistry*
Diterpenes / chemical synthesis
Diterpenes / chemistry*
Diterpenes / isolation & purification
Diterpenes / pharmacology*
Microbial Sensitivity Tests
Mycobacterium tuberculosis / drug effects

Substances

Antitubercular Agents
Diterpenes