A new antitumour ansamitocin from Actinosynnema pretiosum

Guo-Zhu Wei; Lin-Quan Bai; Tao Yang; Juan Ma; Ying Zeng; Yue-Mao Shen; Pei-Ji Zhao

doi:10.1080/14786410902916552

A new antitumour ansamitocin from Actinosynnema pretiosum

Nat Prod Res. 2010 Jul;24(12):1146-50. doi: 10.1080/14786410902916552.

Authors

Guo-Zhu Wei¹, Lin-Quan Bai, Tao Yang, Juan Ma, Ying Zeng, Yue-Mao Shen, Pei-Ji Zhao

Affiliation

¹ State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, P.R. China.

PMID: 20582809
DOI: 10.1080/14786410902916552

Abstract

A new compound of ansamitocin was isolated from the extracts of fermentation medium of mutant strain HGF052 derived from Actinosynnema pretiosum ssp. aurantium ATCC 31565, and identified as N-demethyl-desepoxy-9-methoxy-maytansinol (1) on the basis of extensive spectroscopic methods. Bioassay results showed that compound 1 had cytotoxic activity against HL-60 and BEL-7402 cell lines.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Actinomycetales / chemistry*
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
Cell Line, Tumor
Cell Proliferation / drug effects
HL-60 Cells
Humans
Magnetic Resonance Spectroscopy
Maytansine / analogs & derivatives*
Maytansine / chemistry
Maytansine / pharmacology

Substances

Antineoplastic Agents
Maytansine
ansamitocins