Design and investigation of a series of rhodamine-based fluorescent probes for optical measurements of pH

Quinn A Best; Ruisong Xu; Matthew E McCarroll; Lichang Wang; Daniel J Dyer

doi:10.1021/ol1011967

Design and investigation of a series of rhodamine-based fluorescent probes for optical measurements of pH

Org Lett. 2010 Jul 16;12(14):3219-21. doi: 10.1021/ol1011967.

Authors

Quinn A Best¹, Ruisong Xu, Matthew E McCarroll, Lichang Wang, Daniel J Dyer

Affiliation

¹ Department of Chemistry and Biochemistry, Southern Illinois University, Carbondale, Illinois 62901, USA.

Abstract

A series of structurally similar fluorescent probes (1-4), synthesized from rhodamine B, were designed to optically measure pH. Each probe had a unique "off-on" response as the solution went from basic to acidic. Probes 1-3 exhibited a spirocyclic quenching of the pyronin B fluorophore, whereas probe 4 was quenched by PET from the amine moiety.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Drug Design*
Fluorescent Dyes / chemical synthesis*
Fluorescent Dyes / chemistry*
Hydrogen-Ion Concentration
Optical Phenomena*
Rhodamines / chemistry*

Substances

Fluorescent Dyes
Rhodamines

Abstract

Publication types

MeSH terms

Substances

Grants and funding