Poly(β-cyclodextrin)/curcumin self-assembly: a novel approach to improve curcumin delivery and its therapeutic efficacy in prostate cancer cells

Macromol Biosci. 2010 Oct 8;10(10):1141-51. doi: 10.1002/mabi.201000084.

Abstract

A novel PCD/CUR self-assembly approach for improved curcumin delivery to prostate cancer cells is described. The formation of PCD/CUR was confirmed using FTIR, DSC, TGA, and SEM/TEM, and their stability and solubility under physiological conditions was demonstrated. A mechanism for self-assembly is proposed. Intracellular uptake of the self-assemblies was studied by flow cytometry and immunofluorescence microscopy. The therapeutic efficacy was determined by cell proliferation and colony formation assays using C4-2, DU145 and PC3 prostate cancer cells. The results suggest that the PCD/CUR formulation could be a useful system for improving curcumin delivery and its therapeutic efficacy in prostate cancer.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Antineoplastic Agents* / administration & dosage
  • Antineoplastic Agents* / chemistry
  • Antineoplastic Agents* / therapeutic use
  • Cell Line, Tumor
  • Curcumin* / administration & dosage
  • Curcumin* / chemistry
  • Curcumin* / therapeutic use
  • Drug Delivery Systems
  • Humans
  • Male
  • Models, Molecular
  • Propylene Glycols / administration & dosage
  • Propylene Glycols / chemistry
  • Propylene Glycols / therapeutic use
  • Prostatic Neoplasms / drug therapy*
  • beta-Cyclodextrins / administration & dosage
  • beta-Cyclodextrins / chemistry
  • beta-Cyclodextrins / therapeutic use

Substances

  • Antineoplastic Agents
  • Propylene Glycols
  • beta-Cyclodextrins
  • poly(beta-cyclodextrin)
  • Curcumin