The impact of different doses of food biologically active additive (BAA) on base lipid sea-hydrobions on the condition of water-electrolyte and nitrogen metabolism, proteinosynthesis and hepatobiliary functions of liver has been studied for rats with the experimental cardio-vascular pathology. BAA is the lipid fraction from schoolmaster gonate squid Berryteuthis magister liver, containing 10% of polyunsaturated fatty acids (PUFA) and 50% of alkyldiacylglycerides. In relation to organism's emunctory systems in conditions of experimental cardio-vascular pathology the biotropic dose makes 1 g/kg daily. BAA acts negatively in dose 2 g/kg daily. It is conditioned by aggravation of electrolyte imbalance, lowering of excretion and reabsorption of sodium, potassium, magnesium, metabolites of purine and nitrogen metabolism, stimulation of intoxication and calcification processes, load effect on proteinosynthesis function of rats liver.