Abstract
We performed a single-arm, open-label pilot trial of the anti-inflammatory drug pentoxifylline to reduce systemic inflammation and improve endothelial function, measured by flow-mediated dilation of the brachial artery, in HIV-infected patients not requiring antiretroviral therapy. Pentoxifylline significantly reduced circulating levels of vascular cell adhesion molecule-1 and interferon-gamma-induced protein and significantly improved endothelial function during the 8-week trial. Pentoxifylline may reverse HIV-related endothelial dysfunction by directly inhibiting the endothelial leukocyte adhesion pathway.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Anti-Inflammatory Agents / therapeutic use*
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Brachial Artery / drug effects
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Brachial Artery / physiopathology
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Endothelium, Vascular / drug effects*
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Endothelium, Vascular / physiopathology
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Female
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HIV Infections / complications
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HIV Infections / physiopathology*
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Humans
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Inflammation / drug therapy*
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Inflammation / physiopathology
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Male
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Middle Aged
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Pentoxifylline / therapeutic use*
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Pilot Projects
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Regional Blood Flow / drug effects
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Regional Blood Flow / physiology
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Young Adult
Substances
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Anti-Inflammatory Agents
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Pentoxifylline