Isolation and synthesis of flavonols and comparison of their antioxidant activity

Nat Prod Res. 2010 Jul;24(11):995-1003. doi: 10.1080/14786410902847302.

Abstract

Phytochemical investigation of the leaves of Astragalus beckari yielded four flavonol aglycones, namely kaempferol, quercetin, 5-deoxy kaempferol and fisitin. These isolated compounds were then synthesised in the laboratory using the Algar-Flyn-Oyamad reaction. Antioxidant activity of both the isolated and synthesised flavonoids was compared using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay method. The isolated flavonoids were found to be more active.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antioxidants / metabolism*
  • Astragalus Plant / chemistry*
  • Flavonols / chemical synthesis*
  • Flavonols / chemistry*
  • Kaempferols / chemical synthesis
  • Kaempferols / chemistry
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Plant Leaves / chemistry
  • Quercetin / chemical synthesis
  • Quercetin / chemistry

Substances

  • Antioxidants
  • Flavonols
  • Kaempferols
  • kaempferol
  • Quercetin