[First trimester screening for Down syndrome: five years prospective experience]

J Gynecol Obstet Biol Reprod (Paris). 2010 Sep;39(5):353-61. doi: 10.1016/j.jgyn.2010.04.007. Epub 2010 Jun 11.
[Article in French]

Abstract

First trimester screening for Down syndrome is yet to become the first intention strategy in France. This screening program at 11-14 weeks of gestation using maternal age, fetal nuchal translucency, maternal serum free beta-human chorionic gonadotropin and pregnancy-associated plasma protein-A has already been validated for a long time by many international studies. It seems to improve detection rate and decrease false positive rates. We report here five years prospective experience.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Chorionic Gonadotropin, beta Subunit, Human / blood
  • Down Syndrome / diagnosis*
  • False Positive Reactions
  • Female
  • Gestational Age*
  • Humans
  • Maternal Age
  • Multicenter Studies as Topic
  • Nuchal Translucency Measurement
  • Pregnancy
  • Pregnancy Trimester, First
  • Pregnancy-Associated Plasma Protein-A / analysis
  • Prenatal Diagnosis*
  • Prospective Studies

Substances

  • Chorionic Gonadotropin, beta Subunit, Human
  • Pregnancy-Associated Plasma Protein-A