A patient with lichen sclerosus, Langerhans cell histiocytosis, and invasive squamous cell carcinoma of the vulva

Am J Obstet Gynecol. 2010 Aug;203(2):e7-10. doi: 10.1016/j.ajog.2010.04.023. Epub 2010 Jun 11.

Abstract

We report a patient with vulvar lichen sclerosus, Langerhans cell histiocytosis (LCH), and later vulvar cancer. In LCH, high amounts of non functional Langerhans cells are present in the affected tissue, making it possible that LCH may have contributed to vulvar cancer development in this patient.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use
  • Adult
  • Biopsy, Needle
  • Carcinoma, Squamous Cell / complications
  • Carcinoma, Squamous Cell / pathology*
  • Carcinoma, Squamous Cell / therapy
  • Cell Transformation, Neoplastic / pathology
  • Chemotherapy, Adjuvant
  • Combined Modality Therapy
  • Female
  • Follow-Up Studies
  • Gynecologic Surgical Procedures / methods
  • Histiocytosis, Langerhans-Cell / complications
  • Histiocytosis, Langerhans-Cell / pathology*
  • Histiocytosis, Langerhans-Cell / therapy
  • Humans
  • Immunohistochemistry
  • Neoplasm Invasiveness / pathology
  • Precancerous Conditions / pathology*
  • Radiotherapy, Adjuvant
  • Treatment Outcome
  • Vulvar Lichen Sclerosus / complications
  • Vulvar Lichen Sclerosus / drug therapy
  • Vulvar Lichen Sclerosus / pathology*
  • Vulvar Neoplasms / complications
  • Vulvar Neoplasms / pathology*
  • Vulvar Neoplasms / therapy

Substances

  • Adrenal Cortex Hormones