HAT trick: p300, small molecule, inhibitor

Melanie Ott; Eric Verdin

doi:10.1016/j.chembiol.2010.05.002

HAT trick: p300, small molecule, inhibitor

Chem Biol. 2010 May 28;17(5):417-8. doi: 10.1016/j.chembiol.2010.05.002.

Authors

Melanie Ott¹, Eric Verdin

Affiliation

¹ Gladstone Institute of Virology and Immunology, Department of Medicine, University of California, San Francisco, 1650 Owens St., San Francisco, CA 94158, USA. mott@gladstone.ucsf.edu

PMID: 20534339
DOI: 10.1016/j.chembiol.2010.05.002

Abstract

p300 is an acetyltransferase that targets histone and nonhistone proteins for lysine acetylation. Based on a p300 structure, Bowers et al. (2010) have conducted an in silico screen for active site small molecule inhibitors of p300. We describe this important discovery and its potential therapeutic applications.

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