DBCP: a web server for disulfide bonding connectivity pattern prediction without the prior knowledge of the bonding state of cysteines

Nucleic Acids Res. 2010 Jul;38(Web Server issue):W503-7. doi: 10.1093/nar/gkq514. Epub 2010 Jun 8.

Abstract

The proper prediction of the location of disulfide bridges is efficient in helping to solve the protein folding problem. Most of the previous works on the prediction of disulfide connectivity pattern use the prior knowledge of the bonding state of cysteines. The DBCP web server provides prediction of disulfide bonding connectivity pattern without the prior knowledge of the bonding state of cysteines. The method used in this server improves the accuracy of disulfide connectivity pattern prediction (Q(p)) over the previous studies reported in the literature. This DBCP server can be accessed at http://120.107.8.16/dbcp or http://140.120.14.136/dbcp.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cysteine / chemistry*
  • Disulfides / chemistry*
  • Internet
  • Protein Conformation*
  • Protein Folding
  • Proteins / chemistry
  • Reproducibility of Results
  • Sequence Analysis, Protein
  • Software*
  • User-Computer Interface

Substances

  • Disulfides
  • Proteins
  • Cysteine