Microwave-assisted copper(II)-catalyzed one-pot four-component synthesis of multifunctionalized dihydropyridines

J Comb Chem. 2010 Jul 12;12(4):577-81. doi: 10.1021/cc100060s.

Abstract

A fast and highly efficient copper-catalyzed multicomponent synthesis of 1,4-dihydropyridines under microwave irradiation is described. The protocol utilizes mild reaction conditions with low catalytic loading, leading to high yields. This methodology provides us with biologically active 1,4-dihydropyridine library for medicinal chemistry applications.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Combinatorial Chemistry Techniques*
  • Copper / chemistry*
  • Crystallography, X-Ray
  • Dihydropyridines / chemical synthesis*
  • Dihydropyridines / chemistry
  • Microwaves*
  • Models, Molecular
  • Molecular Structure
  • Small Molecule Libraries
  • Stereoisomerism

Substances

  • Dihydropyridines
  • Small Molecule Libraries
  • Copper