Abstract
A novel and convenient one-pot synthesis of pyrimido[1,6-a]indol-1(2H)-one derivatives through a nucleophilic addition/Cu-catalyzed N-arylation/Pd-catalyzed C-H activation sequential process is described. The reaction of easily prepared ortho-gem-dibromovinyl isocyanates with N-alkyl-anilines gave the desired indole derivatives in moderate to good yields.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aniline Compounds / chemistry
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Catalysis
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Copper / chemistry*
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Indoles / chemical synthesis*
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Indoles / chemistry
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Iodides / chemistry*
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Isocyanates / chemistry
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Molecular Structure
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Palladium / chemistry*
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Pyrimidines / chemical synthesis*
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Pyrimidines / chemistry
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Stereoisomerism
Substances
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Aniline Compounds
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Indoles
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Iodides
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Isocyanates
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Pyrimidines
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pyrimido(1,6-a)indol-1(2H)-one
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Palladium
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Copper
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cuprous iodide
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aniline