Potent in vitro inactivation of both free and cell-associated CCR5- and CXCR4-tropic HIV-1 by common commercial soap bars from South Africa

J Acquir Immune Defic Syndr. 2010 Aug;54(4):340-2. doi: 10.1097/QAI.0b013e3181e3dbf6.

Abstract

We showed herein the potent virucidal effect of soap and water solutions against both CCR5-tropic and CXCR4-tropic cell-free HIV-1 strains, and cytotoxicity for HIV-1-infected lymphocytes during short incubation durations, ranging from 30 seconds to 2 minutes. These observations indicate a rapid inhibitory effect of soap and water on viral infectivity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-HIV Agents / immunology
  • Anti-HIV Agents / pharmacology
  • Antiviral Agents / pharmacology
  • CCR5 Receptor Antagonists
  • Cell Survival / drug effects
  • HIV Infections / immunology*
  • HIV-1 / drug effects*
  • Lymphocytes / drug effects
  • Lymphocytes / immunology
  • Lymphocytes / virology
  • Receptors, CCR5 / physiology*
  • Receptors, CXCR4 / antagonists & inhibitors
  • Receptors, CXCR4 / physiology*
  • Soaps / pharmacology*
  • South Africa

Substances

  • Anti-HIV Agents
  • Antiviral Agents
  • CCR5 Receptor Antagonists
  • Receptors, CCR5
  • Receptors, CXCR4
  • Soaps