Efficient one-pot synthesis of novel spirooxindole derivatives via three-component reaction in aqueous medium

Hui Chen; Daqing Shi

doi:10.1021/cc100056p

Efficient one-pot synthesis of novel spirooxindole derivatives via three-component reaction in aqueous medium

J Comb Chem. 2010 Jul 12;12(4):571-6. doi: 10.1021/cc100056p.

Authors

Hui Chen¹, Daqing Shi

Affiliation

¹ Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, Jiangsu 215123, PR China.

PMID: 20515044
DOI: 10.1021/cc100056p

Abstract

A novel and efficient one-pot synthesis of spiro[indoline-3,4'-pyrazolo[3,4-b]quinoline]dione, spiro[furo[3,4-e]pyrazolo[3,4-b]pyridine-4,3'-indoline]dione, and spiro[indeno[2,1-e]pyrazolo[3,4-b]pyridine-4,3'-indoline]dione derivatives via three-component reaction of isatin, 5-amino-3-methylpyrazole, and 1,3-dicarbonyl compounds in aqueous medium is described. The advantages of this method include high efficiency, mild reaction conditions, convenient operation, and environmentally benign conditions.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Combinatorial Chemistry Techniques*
Crystallography, X-Ray
Models, Molecular
Molecular Structure
Small Molecule Libraries
Spiro Compounds / chemical synthesis*
Spiro Compounds / chemistry
Stereoisomerism
Water / chemistry*

Substances

Small Molecule Libraries
Spiro Compounds
Water