Abstract
A hyperbranched 2-(dimethylamino)ethyl methacrylate (DMAEMA) based polymer has been synthesised by a one-pot in situ deactivation enhanced atom transfer radical polymerisation (DE-ATRP); it exhibits much higher transfection ability than linear poly(DMAEMA) and is comparable to the well known branched poly(ethylene imine) (PEI) and the SuperFect dendrimer but with lower cytotoxicity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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3T3 Cells
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Animals
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Dendrimers / chemistry
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Imines / chemistry
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Methacrylates / chemistry*
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Mice
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Nylons / chemistry*
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Plasmids / genetics
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Plasmids / metabolism
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Polyethylenes / chemistry
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Transfection*
Substances
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Dendrimers
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Imines
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Methacrylates
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Nylons
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Polyethylenes
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poly(2-(dimethylamino)ethyl methacrylate)
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poly(ethylene imine)