A highly effective gene delivery vector--hyperbranched poly(2-(dimethylamino)ethyl methacrylate) from in situ deactivation enhanced ATRP

Chem Commun (Camb). 2010 Jul 14;46(26):4698-700. doi: 10.1039/c0cc00439a. Epub 2010 Jun 1.

Abstract

A hyperbranched 2-(dimethylamino)ethyl methacrylate (DMAEMA) based polymer has been synthesised by a one-pot in situ deactivation enhanced atom transfer radical polymerisation (DE-ATRP); it exhibits much higher transfection ability than linear poly(DMAEMA) and is comparable to the well known branched poly(ethylene imine) (PEI) and the SuperFect dendrimer but with lower cytotoxicity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3T3 Cells
  • Animals
  • Dendrimers / chemistry
  • Imines / chemistry
  • Methacrylates / chemistry*
  • Mice
  • Nylons / chemistry*
  • Plasmids / genetics
  • Plasmids / metabolism
  • Polyethylenes / chemistry
  • Transfection*

Substances

  • Dendrimers
  • Imines
  • Methacrylates
  • Nylons
  • Polyethylenes
  • poly(2-(dimethylamino)ethyl methacrylate)
  • poly(ethylene imine)