Hypofractionation in adjuvant breast radiotherapy

Atif Khan; Bruce G Haffty

doi:10.1016/j.breast.2010.03.004

Hypofractionation in adjuvant breast radiotherapy

Breast. 2010 Jun;19(3):168-71. doi: 10.1016/j.breast.2010.03.004.

Authors

Atif Khan¹, Bruce G Haffty

Affiliation

¹ Department of Radiation Oncology, UMDNJ-RWJMS, Cancer Institute of New Jersey, 195 Little Albany St., New Brunswick, NJ 08901, USA.

PMID: 20511065
DOI: 10.1016/j.breast.2010.03.004

Abstract

Altered fractionation for whole breast irradiation has been extensively studied over the past 20 years, with recent updated publications from several landmark randomized trials. In this review, the radiobiological principles underlying altered fractionation schedules are reviewed, and outcomes, including local control, acute and chronic toxicities from the major published studies are summarized. While the studies published to date provide strong clinical evidence demonstrating acceptable results with hypofractionated regimens, there remain many unanswered questions. The current status of hypofractionated radiation and future directions for research are discussed.

Publication types

Review

MeSH terms

Breast Neoplasms / pathology
Breast Neoplasms / radiotherapy*
Breast Neoplasms / surgery
Dose Fractionation, Radiation*
Female
Humans
Radiotherapy, Adjuvant