Vitamin D analogs

Endocrinol Metab Clin North Am. 2010 Jun;39(2):447-72, table of contents. doi: 10.1016/j.ecl.2010.02.003.

Abstract

Vitamin D has gone through a renaissance with the association of vitamin D deficiency with a wide array of common diseases including breast, colorectal and prostate cancers, cardio-vascular disease, autoimmune conditions and infections. Vitamin D analogs constitute a valuable group of compounds which can be used to regulate gene expression in functions as varied as calcium and phosphate homeostasis, as well as cell growth regulation and cell differentiation of a wide spectrum of cell types. This review will discuss the full range of vitamin D compounds currently available, some of their possible uses, and potential mechanisms of action.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Female
  • Humans
  • Hyperparathyroidism, Secondary / drug therapy
  • Male
  • Mice
  • Neoplasms / drug therapy
  • Psoriasis / drug therapy
  • Rats
  • Receptors, Calcitriol / antagonists & inhibitors*
  • Retinoid X Receptors / metabolism
  • Vitamin D / analogs & derivatives*
  • Vitamin D / metabolism
  • Vitamin D Deficiency / pathology
  • Vitamin D-Binding Protein / metabolism

Substances

  • Receptors, Calcitriol
  • Retinoid X Receptors
  • Vitamin D-Binding Protein
  • Vitamin D