Abstract
Macrophages are involved in the immune and the inflammatory response. The deregulation of their physiological properties is associated with several pathologies such as atherosclerosis and some cancers. Cytokines action on this blood lineage modulates p21WAF1/CIP1 expression. It appears that this protein may play a role in the inflammation regulation through PPAR (peroxysome proliferator-activated receptors) transcription factors, strongly linked to lipid metabolism. It could also be involved in the control of the proliferation of monocytes/macrophages, even if these cells are classically described as devoided of any proliferative capacity.
Publication types
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English Abstract
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Apoptosis / drug effects
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Apoptosis / physiology
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Cell Differentiation / physiology
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Cell Division / physiology
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Cholecalciferol / physiology
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Cyclin-Dependent Kinase Inhibitor p21 / genetics
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Cyclin-Dependent Kinase Inhibitor p21 / physiology*
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Cytokines / physiology
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Gene Expression Regulation / physiology
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Hematopoietic Stem Cells / cytology
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Humans
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Inflammation
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Lipid Metabolism / physiology
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Macrophages / cytology*
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Models, Biological
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Monocytes / cytology*
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Multipotent Stem Cells / cytology
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Myelopoiesis / physiology
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PPAR gamma / agonists
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PPAR gamma / physiology
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Peroxisome Proliferator-Activated Receptors / physiology*
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Signal Transduction / drug effects
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Signal Transduction / physiology
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Tretinoin / pharmacology
Substances
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CDKN1A protein, human
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Cyclin-Dependent Kinase Inhibitor p21
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Cytokines
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PPAR gamma
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Peroxisome Proliferator-Activated Receptors
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Cholecalciferol
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Tretinoin