Tacrolimus-induced polyneuropathy after heart transplantation

Clin Neuropharmacol. 2010 May;33(3):161-2. doi: 10.1097/WNF.0b013e3181dc4f43.

Abstract

Tacrolimus has been often described to induce neuropathy in liver-, pancreas-, and renal-transplanted patients. Here, we report the first case of a 56-year-old woman who developed a progressive symmetric demyelinating sensorimotor polyneuropathy in the distal muscles of the lower limbs after therapy with tacrolimus because of heart transplantation. This condition suddenly reverted after the tacrolimus was stopped.

Publication types

  • Case Reports

MeSH terms

  • Demyelinating Diseases / chemically induced*
  • Demyelinating Diseases / complications
  • Demyelinating Diseases / diagnosis
  • Diagnosis, Differential
  • Disease Progression
  • Drug Monitoring
  • Female
  • Heart Transplantation*
  • Humans
  • Immunosuppressive Agents / adverse effects*
  • Immunosuppressive Agents / therapeutic use
  • Lower Extremity
  • Middle Aged
  • Polyneuropathies / chemically induced*
  • Polyneuropathies / complications
  • Polyneuropathies / diagnosis
  • Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / diagnosis
  • Tacrolimus / adverse effects*
  • Tacrolimus / therapeutic use
  • Treatment Outcome

Substances

  • Immunosuppressive Agents
  • Tacrolimus