Kv1.5-Kv beta interactions: molecular determinants and pharmacological consequences

Teresa González; Miren David; Cristina Moreno; Alvaro Macías; Carmen Valenzuela

doi:10.2174/138955710791384018

Kv1.5-Kv beta interactions: molecular determinants and pharmacological consequences

Mini Rev Med Chem. 2010 Jun;10(7):635-42. doi: 10.2174/138955710791384018.

Authors

Teresa González¹, Miren David, Cristina Moreno, Alvaro Macías, Carmen Valenzuela

Affiliation

¹ Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM), C/Arturo Duperier 4, 28029 Madrid, Spain.

PMID: 20500153
DOI: 10.2174/138955710791384018

Abstract

Kv1.5 channels are homotetramers of alpha-pore subunits mainly present in human atrium and pulmonary vasculature. Thus, Kv1.5 is a pharmacological target for cardiovascular diseases. Kv beta 1.3 assemblies with Kv alpha 1.5 and modifies its gating and pharmacology. A further knowledge of alpha-beta interactions and pharmacology will lead a better design of new drugs.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Anesthetics, Local / chemistry
Anesthetics, Local / pharmacology
Bupivacaine / chemistry
Bupivacaine / pharmacology
Humans
Kv1.3 Potassium Channel / chemistry*
Kv1.3 Potassium Channel / metabolism
Kv1.5 Potassium Channel / chemistry*
Kv1.5 Potassium Channel / metabolism
Protein Binding
Protein Structure, Tertiary

Substances

Anesthetics, Local
KCNAB1 protein, human
Kv1.3 Potassium Channel
Kv1.5 Potassium Channel
Bupivacaine