Two new asterosaponins, archasterosides A and B, from the Vietnamese starfish Archaster typicus and their anticancer properties

Bioorg Med Chem Lett. 2010 Jun 15;20(12):3826-30. doi: 10.1016/j.bmcl.2010.04.005. Epub 2010 Apr 9.

Abstract

New asterosaponins archasterosides A (1), B (2), and the known regularoside A (3) were isolated from the Vietnamese starfish Archaster typicus and structurally elucidated by extensive NMR techniques and chemical transformations. Compounds 1-3 showed moderate cytotoxic activities against HeLa and mouse JB6 P(+) Cl41 cell lines. The most active, 2, induced basal AP-1- and p53-, but not NF-kappaB-transcriptional activations in JB6 Cl41 cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / isolation & purification*
  • Cell Line, Tumor
  • HeLa Cells
  • Humans
  • Magnetic Resonance Spectroscopy
  • Mice
  • Molecular Structure
  • NF-kappa B / genetics
  • Saponins / isolation & purification
  • Saponins / pharmacology*
  • Starfish / chemistry*
  • Transcription Factor AP-1 / genetics
  • Transcriptional Activation / drug effects
  • Tumor Suppressor Protein p53 / genetics

Substances

  • Antineoplastic Agents
  • NF-kappa B
  • Saponins
  • Transcription Factor AP-1
  • Tumor Suppressor Protein p53
  • archasteroside A
  • archasteroside B
  • regularoside A