A novel HLA-B*35 variant, HLA-B*35:02:03, identified by sequence-based typing in a bone marrow donor

Tissue Antigens. 2010 Aug;76(2):152-3. doi: 10.1111/j.1399-0039.2010.01483.x. Epub 2010 May 19.

Abstract

We report the identification of the novel allele human leukocyte antigen-B*35:02:03 that was found during confirmatory high-resolution sequence-based typing of a bone marrow donor. The B*35:02:03 allele has one nucleotide change from B*35:02:01 at position 318 in exon 2 which does not result in an amino acid change (codon 82: CGC --> CGG).

MeSH terms

  • Alleles
  • Base Sequence
  • HLA-B Antigens / genetics*
  • Humans
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • Polymorphism, Single Nucleotide
  • Sequence Homology, Nucleic Acid
  • Tissue Donors

Substances

  • HLA-B Antigens