Spirobisnaphthalenes from fungi and their biological activities

Mini Rev Med Chem. 2010 Sep;10(10):977-89. doi: 10.2174/138955710792007178.

Abstract

Spirobisnaphthalenes have a unique structural feature involving two or three oxygen atoms acting as bridges connecting two original naphthalene subunits. Most of these metabolites isolated from fungi exhibit significant antifungal, antibacterial and cytotoxic properties to show great potential applications in medicine and agriculture. This review focuses on their structural characters and biological activities, as well as their structure-activity relationship, mechanism of action, synthesis and biosynthesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antifungal Agents / chemical synthesis
  • Antifungal Agents / chemistry
  • Antifungal Agents / metabolism
  • Fungi / chemistry*
  • Heterocyclic Compounds, 4 or More Rings / chemistry
  • Heterocyclic Compounds, 4 or More Rings / pharmacology
  • Naphthalenes / chemistry*
  • Naphthalenes / isolation & purification
  • Naphthalenes / pharmacology
  • Spiro Compounds / chemistry*
  • Spiro Compounds / isolation & purification
  • Spiro Compounds / pharmacology
  • Structure-Activity Relationship

Substances

  • Antifungal Agents
  • Heterocyclic Compounds, 4 or More Rings
  • Naphthalenes
  • Spiro Compounds