Abstract
Feline infectious peritonitis is a lethal disease of felids caused by systemic infection with a feline coronavirus. Here, we report identification and analysis of the feline homologue to the human lectin DC-SIGN and show that it is a coreceptor for virulent strains of serotype 1 and serotype 2 feline coronaviruses.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Cats
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Cluster Analysis
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Coronavirus, Feline / physiology*
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Host-Pathogen Interactions*
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Humans
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Lectins, C-Type / genetics
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Lectins, C-Type / metabolism*
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Molecular Sequence Data
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Phylogeny
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Receptors, Cell Surface / genetics
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Receptors, Cell Surface / metabolism*
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Sequence Analysis, DNA
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Sequence Homology, Amino Acid
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Virus Attachment*
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Virus Internalization*
Substances
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Lectins, C-Type
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Receptors, Cell Surface