Abstract
Synthesis of novel beta-lactam fused spiroisoxazolidine chromanones and tetralones ring systems has been achieved by intermolecular 1,3-dipolar cycloaddition reaction of bicyclic nitrone with unusual dipolarophiles, arylidene chromanones/tetralones under different reaction conditions. The synthesized compounds were evaluated for antimicrobial activities. It was observed that two of the synthesized compounds exhibited relatively good antibacterial and antifungal activities.
Copyright 2010 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemical synthesis*
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Antifungal Agents / chemical synthesis*
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Chromans / chemical synthesis*
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Chromans / pharmacology
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Humans
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Isoxazoles / chemical synthesis
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Isoxazoles / pharmacology
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Microbial Sensitivity Tests
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Plants / microbiology
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Spiro Compounds / chemical synthesis
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Structure-Activity Relationship
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Tetralones / chemical synthesis*
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Tetralones / pharmacology
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beta-Lactams / chemical synthesis*
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beta-Lactams / pharmacology
Substances
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Anti-Bacterial Agents
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Antifungal Agents
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Chromans
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Isoxazoles
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Spiro Compounds
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Tetralones
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beta-Lactams