Cyclodextrins: more than pharmaceutical excipients

Mini Rev Med Chem. 2010 Jul;10(8):715-25. doi: 10.2174/138955710791572479.

Abstract

Cyclodextrins are pharmaceutical excipients used to enhance the solubility, stability, safety and bioavailability of drugs. Recent findings have shown them to display adjuvant activity in vaccine therapy and prophylactic and therapeutic activity in the treatment of several host-pathogen infections. This article focuses on their activity and mechanism of action.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology
  • Antiparasitic Agents / chemistry
  • Antiparasitic Agents / pharmacology
  • Antiviral Agents / chemistry
  • Antiviral Agents / pharmacology
  • Cyclodextrins / chemistry*
  • Cyclodextrins / pharmacology
  • Excipients / chemistry*
  • Excipients / pharmacology
  • Immunologic Factors / chemistry
  • Immunologic Factors / pharmacology
  • Protein Folding

Substances

  • Anti-Bacterial Agents
  • Antiparasitic Agents
  • Antiviral Agents
  • Cyclodextrins
  • Excipients
  • Immunologic Factors