Synthesis of 1,2,4-triazolines and triazoles utilizing oxazolones

Rahman Shah Zaib Saleem; Jetze J Tepe

doi:10.1021/jo100716m

Synthesis of 1,2,4-triazolines and triazoles utilizing oxazolones

J Org Chem. 2010 Jun 18;75(12):4330-2. doi: 10.1021/jo100716m.

Authors

Rahman Shah Zaib Saleem¹, Jetze J Tepe

Affiliation

¹ Department of Chemistry, Michigan State University, East Lansing, Michigan 48823, USA.

PMID: 20481587
DOI: 10.1021/jo100716m

Abstract

We describe herein a convenient method for the synthesis of 1,2,4-triazolines using oxazolones and azodicarboxylates. Subsequent treatment of these 1,2,4-triazolines with NaOH provides efficient access to the corresponding triazoles.