CuH-catalyzed enantioselective 1,2-reductions of alpha,beta-unsaturated ketones

Ralph Moser; Zarko V Bosković; Christopher S Crowe; Bruce H Lipshutz

doi:10.1021/ja102689e

CuH-catalyzed enantioselective 1,2-reductions of alpha,beta-unsaturated ketones

J Am Chem Soc. 2010 Jun 16;132(23):7852-3. doi: 10.1021/ja102689e.

Authors

Ralph Moser¹, Zarko V Bosković, Christopher S Crowe, Bruce H Lipshutz

Affiliation

¹ Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, USA.

Abstract

The first study on a general technology for arriving at valued nonracemic allylic alcohols using asymmetric ligand-accelerated catalysis by copper hydride is described.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Alcohols / chemistry
Catalysis
Coordination Complexes / chemistry*
Ketones / chemistry*
Oxidation-Reduction
Stereoisomerism
Substrate Specificity

Substances

Alcohols
Coordination Complexes
Ketones

Grants and funding

R01 GM086485/GM/NIGMS NIH HHS/United States