First detection of CTX-M and SHV extended-spectrum beta-lactamases in Escherichia coli urinary tract isolates from dogs and cats in the United States

Antimicrob Agents Chemother. 2010 Aug;54(8):3489-92. doi: 10.1128/AAC.01701-09. Epub 2010 May 17.

Abstract

One hundred fifty canine and feline Escherichia coli isolates associated with urinary tract infections were screened for the presence of extended-spectrum beta-lactamase (ESBL) genes. Out of 60 isolates suspected to be ESBL positive based on antimicrobial susceptibility testing, 11 ESBLs were identified, including one SHV-12 gene, one CTX-M-14 gene, and nine CTX-M-15 genes. This study provides the first report of CTX-M- and SHV-type ESBLs in dogs and cats in the United States.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Bacterial Agents / pharmacology
  • Cat Diseases / microbiology*
  • Cats
  • DNA, Bacterial / analysis
  • DNA, Bacterial / genetics
  • Dog Diseases / microbiology*
  • Dogs
  • Escherichia coli / drug effects
  • Escherichia coli / enzymology*
  • Escherichia coli / genetics
  • Escherichia coli Infections / microbiology
  • Escherichia coli Infections / veterinary*
  • Microbial Sensitivity Tests
  • Polymerase Chain Reaction
  • Sequence Analysis, DNA
  • United States
  • Urinary Tract Infections / microbiology
  • Urinary Tract Infections / veterinary*
  • beta-Lactamases / genetics*

Substances

  • Anti-Bacterial Agents
  • DNA, Bacterial
  • beta-lactamase CTX-M-14
  • beta-lactamase CTX-M-15
  • beta-lactamase SHV-12
  • beta-Lactamases