Abstract
FNR-dependent activation of the Escherichia coli K-12 nrf promoter is downregulated by the nitric oxide-sensitive NsrR protein together with the nucleoid-associated protein IHF, which bind to overlapping targets adjacent to the DNA site for FNR. The NsrR target is inactivated by mutation at the Salmonella enterica serovar Typhimurium nrf promoter.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Base Sequence
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Cytochrome c Group / genetics
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Cytochrome c Group / metabolism
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DNA, Bacterial
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / metabolism*
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Down-Regulation
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Escherichia coli K12 / genetics*
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Escherichia coli K12 / metabolism*
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Escherichia coli Proteins / genetics
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Escherichia coli Proteins / metabolism*
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Gene Expression Regulation, Bacterial / physiology
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Mutation
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Nitric Oxide / metabolism*
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Promoter Regions, Genetic / physiology*
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Salmonella typhimurium / genetics
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Salmonella typhimurium / metabolism
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Transcription Factors / genetics
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Transcription Factors / metabolism*
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Transcription, Genetic
Substances
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Cytochrome c Group
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DNA, Bacterial
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DNA-Binding Proteins
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Escherichia coli Proteins
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NsrR protein, E coli
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Transcription Factors
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Nitric Oxide
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cytochrome C-552