Abstract
The easy and efficient aromatization of various 1,4-dihydropyridines was investigated using various metal nitrates, trinitratocerium(IV) bromate (TNCB), and tetrabutyl ammonium periodate (TBAP) as oxidant in acetic acid at 100 degrees C, as well as hexamethylenetetramine-iodine (HMTAI) reflux in methanol. The efficient conversion of nifedipine-d(3) to dehydronifedipine-d(3) as an internal standard can be used in the measurement of nifedipine concentration in a body.
Copyright 2010 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Calcium Channel Blockers / chemistry
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Deuterium / chemistry*
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Dihydropyridines / chemistry*
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Humans
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Metals / chemistry
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Methenamine / chemistry
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Nifedipine / analogs & derivatives*
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Nifedipine / analysis*
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Nifedipine / chemical synthesis
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Nifedipine / chemistry*
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Nifedipine / standards
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Nitrates / chemistry
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Quaternary Ammonium Compounds / chemistry
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Radiopharmaceuticals / chemical synthesis
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Vasodilator Agents / chemistry
Substances
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Calcium Channel Blockers
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Dihydropyridines
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Metals
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Nitrates
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Quaternary Ammonium Compounds
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Radiopharmaceuticals
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Vasodilator Agents
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dehydronifedipine
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1,4-dihydropyridine
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Deuterium
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tetrabutylammonium
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Nifedipine
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Methenamine