Enhancement of neural stochastic firing in cochlear implant stimulation by the addition of noise: a computational study of the influence of stimulation settings and spontaneous activity

Alessia Paglialonga; Serena Fiocchi; Paolo Ravazzani; Gabriella Tognola

doi:10.1016/j.compbiomed.2010.04.004

Enhancement of neural stochastic firing in cochlear implant stimulation by the addition of noise: a computational study of the influence of stimulation settings and spontaneous activity

Comput Biol Med. 2010 Jun;40(6):597-606. doi: 10.1016/j.compbiomed.2010.04.004. Epub 2010 May 14.

Authors

Alessia Paglialonga¹, Serena Fiocchi, Paolo Ravazzani, Gabriella Tognola

Affiliation

¹ Istituto di Ingegneria Biomedica, Consiglio Nazionale delle Ricerche, ISIB-CNR, Piazza Leonardo da Vinci 32, I-20133 Milano, Italy. alessia.paglialonga@polimi.it

PMID: 20471638
DOI: 10.1016/j.compbiomed.2010.04.004

Abstract

It is known that, in cochlear implants (CIs), the addition of noise to CI stimuli may enhance the stochastic firing in the auditory nerve (AN). The aim of this study was to investigate, by using a model of a fiber of the AN the influence of CI stimulation settings (i.e., stimulation rate and stimulus magnitude) and fiber spontaneous activity on the enhancement of stochastic firing when CI stimuli are combined with noise. Results showed that the stimulation rate had an effect on the enhancement of stochastic firing in the AN, whereas the stimulus magnitude and the spontaneous firing rate had no influence.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Action Potentials / physiology*
Cochlear Implants*
Cochlear Nerve / physiology*
Computational Biology
Computer Simulation*
Electric Stimulation
Humans
Models, Neurological*
Stochastic Processes