Abstract
The aim of this review is to summarize the most comprehensive results in the field of bis-aromatic compounds targeting DNA and RNA, whereby both aromatic units of small molecule bind to the polynucleotide by the aromatic stacking interactions. The most recent results about structure - DNA/RNA binding affinity, selectivity and biological implications are discussed for bis-intercalators, sterically restricted macrocyclic and threading bis-aromatics and intercalator - nucleobase conjugates.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Base Sequence
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DNA, Single-Stranded / genetics*
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DNA, Single-Stranded / metabolism*
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Humans
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Hydrocarbons, Aromatic / chemistry*
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Hydrocarbons, Aromatic / metabolism*
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Intercalating Agents / chemistry
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Intercalating Agents / metabolism
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RNA, Double-Stranded / genetics*
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RNA, Double-Stranded / metabolism*
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Structure-Activity Relationship
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Water / chemistry*
Substances
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DNA, Single-Stranded
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Hydrocarbons, Aromatic
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Intercalating Agents
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RNA, Double-Stranded
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Water