Steroidal alkaloids of Veratrum lobelianum Bernh. and Veratrum nigrum L

Z Naturforsch C J Biosci. 2010 Mar-Apr;65(3-4):195-200. doi: 10.1515/znc-2010-3-405.

Abstract

Twelve steroidal alkaloids were isolated from four populations of Veratrum lobelianum Bernh. and Veratrum nigrum L. Full NMR data for veralosinine (1), and extensive 1H NMR data for veralosine (3) and teinemine (5) are presented here for the first time. (+/-)-15-O-(2-Methylbutyroyl)germine (10) is undescribed up to now. The antiproliferative activities of veranigrine, veralosinine, and neogermitrine have shown that they are a perspective for further studies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bulgaria
  • Cell Division / drug effects*
  • Leukemia L5178 / pathology
  • Magnetic Resonance Spectroscopy
  • Medicine, Traditional
  • Mice
  • Models, Molecular
  • Mongolia
  • Phytosterols / pharmacology
  • Veratrum / chemistry*
  • Veratrum Alkaloids / chemistry
  • Veratrum Alkaloids / isolation & purification*
  • Veratrum Alkaloids / pharmacology

Substances

  • Phytosterols
  • Veratrum Alkaloids
  • veranigrine